| 27803 Biological Sequence Analysis |
| Danish title: Biologisk sekvensanalyse |
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Language: English ECTS-creditpoints: 11,7
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| Type: course at phd level |
| Program: Chemical Engineering |
| Scope and form: Lectures and execises |
| Examination: Pass/fail |
Contents: The course will cover biological macromolecules fra sequence analysis through 3D-structure to the understanding og biological function at the molecualr level. The following topics will be covered;
-Nucelotide and amino acid sequence: advanced multipel alignment methods, sequenceing, database overview, gene finding, phylogeny reconstruction.
-Protein and DNA structural alignment, homology modelling, threading, proteins surface prediction, protein secondary structure prediction, DNA bending.
-protein and gene function: protein dynamics, catalytic mechanisms, binding sites and binding energies, docking, energy minimisation, structure based drug design, gene function prediction.
The course will consist of lectures and computer exercises, where the students will be introduced to a range of computaltional methods used in the field and to Internet biocomputing services available |
Contact: Søren Brunak, building 208, (+45) 4525 2477, soren.brunak@biocentrum.dtu.dk
Flemming Jørgensen, building 413, (+45) 4525 1308, fj@adm.dtu.dk |
| Department: 027 BioCentrum-DTU |
| Keywords: prediction, DNA, proteins, sequence analysis, neural networks |
| Signup: Johanne Keiding tlf.: 45 25 24 77 email:johanne@cbs.dtu.dk |
| Updated: 06-12-2001 |
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