| Recommended semester: 4th -7th semester |
| Scope and form: ½ weekly module. Theory at lectures, group work and exercises. |
| Evaluation: Written exam or project report
|
| Examination: 13-scale |
| Previous course: C2131.21235 |
| Prerequisites: 26124 / 21215 / 25111 |
| Preferred prerequisites: 25211 |
| No credit points with: C2131 / 21235 |
| Aim: To provide insight into the interplay between the properties of biological trace elements, particularly metals, and the structure and function of biological macromolecules and membranes. Further, to illustrate these relationships by specific metal-containing biomolecular systems, and by biotechnological and environmental aspects of bioinorganic chemistry. |
| Contents: Biological essentiality, distribution and uptake of chemical trace elements. Bioinorganic chemical techniques. Elements of transition metal coordination chemistry. Biological organization (protein- and membrane structure; solvation of biological macromolecules, active site organization, pigment orientation in protein complexes). Biomineralization. Metals in biological electron transport (photosynthesis, respiration, redox enzymes), and the physical nature of electron transfer. Coordination chemistry in biological dioxygen transport. Hydrolytic metalloenzymes. Metal activated enzymes (calcium, magnesium). Redox metalloenzymes. Dinitrogen fixation. Biological mechanisms of metal transport. Biological ultratrace elements. Bioinorganic chemistry and biotechnology (Environmental bioinorganic chemistry, chemotherapy, "biochips" and nanoscale bioinorganic chemistry, etc). |
| Remarks: Part of the advanced course group of the institute within coordination chemistry and bioinorganic chemistry, which among others include 26124 Coordination Chemistry and 26122 Experimental course in Coordination Chemistry and Bioinorganic Chemistry. Besides related to bio-chemical courses. |
| Contact: Jens Ulstrup, building 207, (+45) 4525 2359, ju@kemi.dtu.dk |
| Department: 026 Department of Chemistry |
| Keywords: biological trace elements, oxygen transport, biomineralisation, photosynthesis/respiration, metalloenzymes |
| Updated: 23-08-2001 |
