| Type: | Ph.D.-level
Language: English |
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Previous course: C2131
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No credit points with: C2131
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Prerequisite: C2112/21215/C2113/21210/C2114/21211.C2202/21262.C3201/24001
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Recommended semester: 5th semester
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Scope and form: 2 weekly modules. Theory at lectures, group work and exercises.
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Examination: Written examination or special assignment (13-scale)
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| Contact person: | Jens Ulstrup, Building 207, Tel. +45 4525 2359, email ju@kemi.dtu.dk |
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Department: Department of Chemistry
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Aim: To provide insight into the interplay between the properties of biological trace elements, particularly metals, and the structure and function of biological macromolecules and membranes. Further, to illustrate these relationships by specific metal-containing biomolecular systems, and by technological and environmental aspects of bioinorganic chemistry.
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Contents: Biological essentiality, distribution and uptake of chemical trace elements. Bioinorganic chemical techniques. Elements of transition metal coordination chemistry. Biological organization (protein- and membrane structure; solvation of biological macromolecules, active site organization, pigment orientation in protein complexes). Biomineralization. Metals in biological electron transport (photosynthesis, respiration, redox enzymes), and the physical nature of electron transfer. Coordination chemistry in biological dioxygen transport. Hydrolytic metalloenzymes. Metal activated enzymes (calcium, magnesium). Redox metalloenzymes. Dinitrogen fixation. Biological mechanisms of metal transport. Biological ultratrace elements. Applied bioinorganic chemistry. (Environmental bioinorganic chemistry, chemotherapy, "biochips", etc).
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