| Type: | Ph.D.-level, Open University
Language: English |
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Compulsory: masters degree in Chemical Engeneering
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Recommended semester: 7th - 9th semester
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Scope and form: theory.
One double lecture per day for two weeks including group work.
11 consecutive days and 2-3 hours per day plus homework. Starting time 9:15.
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Examination: Evaluation of report(s) (Pass/fail)
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Remarks: Deadline 17-04- 2002
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Department: Department of Organic Chemistry
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Aim: The aim is to give an introduction to the field of combinatorial and solid-phase chemistry.
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Contents: Introduction to and history of combinatorial science, both in solution and on solid-phase.The mathematics of combinatorics. Molecular diversity (structural and functional properties, the combinatorial display and size). Planning of a library synthesis.Resins and handles for solid-phase peptide, oligonucleotide, oligosaccharide, and organic synthesis. Methods for attachment and cleavage; stability and compatibility during synthesis. Organic syntheses on solid-phase. Analytical techniques. Assays and screening. Phage display libraries Application of combinatorial chemistry in the pharma industry
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